- Confirm asystole in two leads
- Search for and treat possible causes: tension pneumothorax, hypovolemia, hypoxia, drug overdose, hypo/hyperthermia, pulmonary embolism, acidosis, cardiac tamponade
- Epinephrine 1 mg (10 ml of 1:10,000) IV/IO. Repeat every 3-5 minutes for duration of cardiac arrest
- Vasopressin 40 units IV/IO for 1st or 2nd dose of Epinephrine
- Consider Sodium bicarbonate 1 mEq/kg IV/IO for pre-existing conditions
- Consider termination
OR